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Recombinant IL-33 anticorps

IL33 Reactivité: Souris ELISA, Func Hôte: Souris Monoclonal Bondy-1-1 unconjugated Recombinant Antibody
N° du produit ABIN1169169
  • Antigène Voir toutes IL-33 (IL33) Anticorps
    IL-33 (IL33) (Interleukin 33 (IL33))
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    • 83
    • 47
    • 39
    • 9
    • 1
    Souris
    Hôte
    • 102
    • 26
    • 8
    • 3
    • 2
    • 1
    • 1
    Souris
    Clonalité
    • 114
    • 29
    Monoclonal
    Conjugué
    • 72
    • 23
    • 13
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IL-33 est non-conjugé
    Application
    • 85
    • 67
    • 36
    • 29
    • 19
    • 15
    • 14
    • 14
    • 13
    • 11
    • 9
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    ELISA, Functional Studies (Func)
    Specificité
    Recognizes mouse IL-33.
     Réactivité croisée
    Souris
    Purification
    Purified from HEK 293 cell culture supernatant.
    Pureté
    >95 % (SDS-PAGE)
    niveau d'endotoxine
    <0.01EU/μg purified protein (LAL test, Lonza).
    Immunogène
    Mouse recombinant IL-33.
    Clone
    Bondy-1-1
    Isotype
    IgG2b
    Top Product
    Discover our top product IL33 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    anti-IL-33 (mouse), monoclonal antibody (recombinant) (Bondy-1-1) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the mouse lgG2b Fc domain.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol
    Agent conservateur
    Without preservative
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Date de péremption
    12 months
  • Antigène
    IL-33 (IL33) (Interleukin 33 (IL33))
    Autre désignation
    IL-33 (IL33 Produits)
    Synonymes
    anticorps IL33, anticorps C9orf26, anticorps DVS27, anticorps IL1F11, anticorps NF-HEV, anticorps NFEHEV, anticorps RP11-575C20.2, anticorps 9230117N10Rik, anticorps Il-33, anticorps Il1f11, anticorps RGD1311155, anticorps interleukin 33, anticorps IL33, anticorps Il33
    Sujet
    Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases and sepsis. Anti-IL-33, mAb (recombinant) (blocking) (Bondy-1-1) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.
    UniProt
    Q8BVZ5
    Pathways
    Production of Molecular Mediator of Immune Response
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