Indoleamine 2,3-Dioxygenase 1 (IDO1) anticorps

Détails pour le produit réf. ABIN1169195
Antigène
  • INDO
  • ido
  • indo
  • IDO
  • cd107b
  • IDO1
  • IDO-1
  • Ido
  • Indo
  • indoleamine 2,3-dioxygenase 1
  • indoleamine 2,3-dioxygenase 1 L homeolog
  • indoleamine 2,3-dioxygenase 1-like
  • IDO1
  • ido1.L
  • ido1
  • Ido1
  • LOC100050681
Reactivité
Souris
174
49
33
5
3
3
1
1
Hôte
Lapin
115
55
20
2
1
Clonalité
Polyclonal
Conjugué
Inconjugué
9
7
5
3
3
3
3
3
3
2
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
141
79
55
37
27
14
13
10
8
4
4
3
2
1
1
Options
Immunogène Recombinant mouse IDO.
Specificité Recognizes mouse IDO. Detects a band of ~45 kDa by Western blot.
 Réactivité croisée Souris
Stérilité 0.2 μm filtered
Antigène
Autre désignation IDO (IDO1 Antibody Extrait)
Sujet IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T-cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T-cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
UniProt P28776
Pathways Activated T Cell Proliferation
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Agent conservateur Without preservative
Stock 4 °C,-20 °C
Stockage commentaire Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.
Date de péremption 6 months
Images (Fournisseur)
Western Blotting (WB) image for anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibody (ABIN1169195) Western blot analysis of mouse IDO using anti-IDO (mouse), pAb at 1:2,000 dilution. ...
Immunohistochemistry (IHC) image for anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibody (ABIN1169195) Immunohistochemical staining of mouse gut using anti-IDO (mouse), pAb . Colorization ...
Produit citée dans: Jung, Lee, Chang, Lee, Jeong, Lee, Park, Han, Seo, Lee, Park: "Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 5, pp. 3146-54, 2009 (PubMed).

Yen, Lin, Chen, Huang, Yang, Chang, Lei, Lai: "A novel cancer therapy by skin delivery of indoleamine 2,3-dioxygenase siRNA." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 2, pp. 641-9, 2009 (PubMed).

Cook, Bickerstaff, Wang, Nadasdy, Della Pelle, Colvin, Orosz: "Spontaneous renal allograft acceptance associated with "regulatory" dendritic cells and IDO." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 5, pp. 3103-12, 2008 (PubMed).

Yadav, Burudi, Alirezaei, Flynn, Watry, Lanigan, Fox: "IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4." dans: Glia, Vol. 55, Issue 13, pp. 1385-96, 2007 (PubMed).

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