Granulin anticorps

N° du produit ABIN1169392

Cet anticorps Rat Polyclonal détecte spécifiquement Granulin dans WB et ELISA. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour Granulin anticorps (ABIN1169392)

Antigène: Granulin (GRN)

Reactivité: Souris

Hôte: Rat

Clonalité: Polyclonal

Conjugué: Cet anticorp Granulin est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Granulin anticorps

Fonction: anti-Progranulin (mouse), pAb

Specificité: Recognizes mouse progranulin. Detects a band of ~90 kDa by Western blot. Weakly cross-reacts with human progranulin.

Réactivité croisée (Details): Weakly cross-reacts with human progranulin.

Attributs du produit: Polyclonal Antibody. Recognizes mouse progranulin. Detects a band of ~90 kDa by Western blot. Weakly cross-reacts with human progranulin. Source: Rat. Applications: ELISA, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Stérilité: 0.2 μm filtered

Immunogène: Recombinant mouse progranulin.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Agent conservateur: Without preservative

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Détails sur Granulin

Antigène: Granulin (GRN)

Autre désignation: Progranulin

Sujet:

Alternate Names/Synonyms: Proepithelin, PEPI, PC Cell-derived Growth Factor

Product Description: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

UniProt: P28798