Integrin beta 7 Chain anticorps

N° du produit ABIN1176850

Cet anticorps Rat Monoclonal détecte spécifiquement Integrin beta 7 Chain dans BR et FACS. Il présente une réactivité avec des échantillons de Humain et Souris. Il a été cité dans 6+ publications.

Aperçu rapide pour Integrin beta 7 Chain anticorps (ABIN1176850)

Antigène: Integrin beta 7 Chain

Reactivité: Humain, Souris

Hôte: Rat

Clonalité: Monoclonal

Application: Blocking Reagent (BR), Flow Cytometry (FACS)

Clone: FIB27

Détail du produit

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Immunogène: AKR/Cum mouse spontaneous T lymphoma cell line TK1

Isotype: IgG2a kappa

Information d'application

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Référence

Karecla, Green, Bowden, Coadwell, Kilshaw: "Identification of a binding site for integrin alphaEbeta7 in the N-terminal domain of E-cadherin." dans: The Journal of biological chemistry, Vol. 271, Issue 48, pp. 30909-15, (1997) (PubMed).

Tidswell, Pachynski, Wu, Qiu, Dunham, Cochran, Briskin, Kilshaw, Lazarovits, Andrew, Butcher, Yednock, Erle: "Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 3, pp. 1497-505, (1997) (PubMed).

Andrew, Berlin, Honda, Yoshino, Hamann, Holzmann, Kilshaw, Butcher: "Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 9, pp. 3847-61, (1994) (PubMed).

Lefrançois, Barrett, Havran, Puddington: "Developmental expression of the alpha IEL beta 7 integrin on T cell receptor gamma delta and T cell receptor alpha beta T cells." dans: European journal of immunology, Vol. 24, Issue 3, pp. 635-40, (1994) (PubMed).

Roberts, Kilshaw: "The mucosal T cell integrin alpha M290 beta 7 recognizes a ligand on mucosal epithelial cell lines." dans: European journal of immunology, Vol. 23, Issue 7, pp. 1630-5, (1993) (PubMed).

Kilshaw, Murant: "Expression and regulation of beta 7(beta p) integrins on mouse lymphocytes: relevance to the mucosal immune system." dans: European journal of immunology, Vol. 21, Issue 10, pp. 2591-7, (1991) (PubMed).

Détail du antigène

Antigène: Integrin beta 7 Chain

Sujet: The FIB27 antibody reacts with the integrin beta7 chain (also known as integrin betap), which is found in association with either of two alpha chains. alpha4beta7 (LPAM-1) is expressed on most mature lymphocytes and on small subsets of thymic and bone marrow cells, it interacts with several ligands, including VCAM-1, fibronectin, and MAdCAM-1. alphaIELbeta7 is found primarily on intestinal intraepithelial lymphocytes (IEL), and it may be involved in interactions between IEL and epithelia via recognition of E-cadherin. The FIB27 antibody blocks beta7 integrin-mediated adhesion to fibronectin, MAdCAM-1, and VCAM-1, and it cross-reacts with human integrin beta7.