ICAM1 anticorps

N° du produit ABIN1177012

Détail du produit anti-ICAM1 anticorps

Antigène: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Reactivité: Souris

Hôte: Hamster arménien

Clonalité: Monoclonal

Conjugué: Cet anticorp ICAM1 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR)

Marque: BD Pharmingen™

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Immunogène: Not reported

Clone: 3E2

Isotype: IgG1 kappa

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Références pour anticorps anti-ICAM1 (ABIN1177012)

Masten, Yates, Pollard Koga, Lipscomb: "Characterization of accessory molecules in murine lung dendritic cell function: roles for CD80, CD86, CD54, and CD40L." dans: American journal of respiratory cell and molecular biology, Vol. 16, Issue 3, pp. 335-42, (1997) (PubMed).

Gonzalo, Martinez, Springer, Gutierrez-Ramos: "ICAM-1 is required for T cell proliferation but not for anergy or apoptosis induced by Staphylococcus aureus enterotoxin B in vivo." dans: International immunology, Vol. 7, Issue 10, pp. 1691-8, (1996) (PubMed).

Kelly, Williams, Colvin, Meehan, Springer, Gutierrez-Ramos, Bonventre: "Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury." dans: The Journal of clinical investigation, Vol. 97, Issue 4, pp. 1056-63, (1996) (PubMed).

Nishio, Podack: "Rapid induction of tumor necrosis factor cytotoxicity in naive splenic T cells by simultaneous CD80 (B7.1) and CD54 (ICAM-1) co-stimulation." dans: European journal of immunology, Vol. 26, Issue 9, pp. 2160-4, (1996) (PubMed).

Soriano, Lipton, Wang, Xiao, Springer, Gutierrez-Ramos, Hickey: "Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury." dans: Annals of neurology, Vol. 39, Issue 5, pp. 618-24, (1996) (PubMed).

Nishio, Spielman, Lee, Nelson, Podack: "CD80 (B7.1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 10, pp. 4347-53, (1996) (PubMed).

Springer: "Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm." dans: Cell, Vol. 76, Issue 2, pp. 301-14, (1994) (PubMed).

Xu, Gonzalo, St Pierre, Williams, Kupper, Cotran, Springer, Gutierrez-Ramos: "Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice." dans: The Journal of experimental medicine, Vol. 180, Issue 1, pp. 95-109, (1994) (PubMed).

Isobe, Yagita, Okumura, Ihara: "Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1." dans: Science (New York, N.Y.), Vol. 255, Issue 5048, pp. 1125-7, (1992) (PubMed).

Siu, Hedrick, Brian: "Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 143, Issue 11, pp. 3813-20, (1990) (PubMed).

Springer: "Adhesion receptors of the immune system." dans: Nature, Vol. 346, Issue 6283, pp. 425-34, (1990) (PubMed).

Détails sur ICAM1

Antigène: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Autre désignation: CD54 (ICAM-1) (ICAM1 Produits)

Synonymes: anticorps BB2, anticorps CD54, anticorps P3.58, anticorps Icam-1, anticorps Ly-47, anticorps MALA-2, anticorps ICAM, anticorps ICAM-1, anticorps ICAM1, anticorps intercellular adhesion molecule 1, anticorps intercellular adhesion molecule-1, anticorps ICAM1, anticorps Icam1, anticorps ICAM-1

Classe de substances: Viral Protein

Sujet: The 3E2 antibody reacts with CD54 (ICAM-1), a 95-kDa member of the Ig superfamily found on lymphocytes, vascular endothelium, high endothelial venules, epithelial cells, macrophages, and dendritic cells. ICAM-1 is a ligand for LFA1 (CD11a/CD18) and Mac-1 (CD11b/CD18). Its expression is upregulated upon stimulation by inflammatory mediators such as cytokines and LPS. Studies with mouse Icam1-transfected antigen-presenting cells, with CD54-blocking antibodies, and in CD54-deficient mice indicate that CD54 participates in inflammatory reactions and antigen-specific immune responses. In addition, there is evidence that CD54 is a receptor involved in MHC-non-restricted responses to weakly immunogenic tumor cells. The 3E2 antibody has been reported to block in vitro and in vivo intracellular adhesion events involved in immune responses.
Synonyms: ICAM-1

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling