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NCR1 anticorps

NCR1 Reactivité: Humain FACS, Func Hôte: Souris Monoclonal 9E2-NKp46 unconjugated
N° du produit ABIN1177346
  • Antigène Voir toutes NCR1 Anticorps
    NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))
    Reactivité
    • 72
    • 54
    • 20
    • 9
    • 4
    • 4
    Humain
    Hôte
    • 55
    • 25
    • 15
    Souris
    Clonalité
    • 58
    • 37
    Monoclonal
    Conjugué
    • 35
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Cet anticorp NCR1 est non-conjugé
    Application
    • 51
    • 28
    • 23
    • 13
    • 13
    • 10
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func)
    Marque
    BD Pharmingen™
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Stérilité
    0.2 μm filtered
    niveau d'endotoxine
    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
    Clone
    9E2-NKp46
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product NCR1 Anticorps primaire
  • Indications d'application
    This NA/LE™ format is useful for in vitro functional studies.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
    Agent conservateur
    Azide free
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Mandelboim, Porgador: "NKp46." dans: The international journal of biochemistry & cell biology, Vol. 33, Issue 12, pp. 1147-50, (2001) (PubMed).

    Sivori, Pende, Bottino, Marcenaro, Pessino, Biassoni, Moretta, Moretta et al.: "NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against ..." dans: European journal of immunology, Vol. 29, Issue 5, pp. 1656-66, (1999) (PubMed).

    Sivori, Vitale, Morelli, Sanseverino, Augugliaro, Bottino, Moretta, Moretta: "p46, a novel natural killer cell-specific surface molecule that mediates cell activation." dans: The Journal of experimental medicine, Vol. 186, Issue 7, pp. 1129-36, (1997) (PubMed).

  • Antigène
    NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))
    Autre désignation
    NKp46 (NCR1 Produits)
    Synonymes
    anticorps CD335, anticorps LY94, anticorps NK-p46, anticorps NKP46, anticorps Ly94, anticorps NKp46, anticorps KILR-1, anticorps Nk-p46, anticorps Nkp46, anticorps natural cytotoxicity triggering receptor 1, anticorps NCR1, anticorps Ncr1
    Sujet
    NKp46, a major cytoxicity receptor of NK cells, is a type I membrane glycoprotein (46 kDa) is expressed on resting and activated NK cells. Its extracellular region contains two C2-type, Ig-like domains. The transmembrane domain contains a positively charged amino acid (Arg) which could be involved in stabilizing the association with CD3zeta. Its intracellular region does not contain immunoreceptor tyrosine-based activating motifs (ITAM), but it is linked to intracytoplasmic transduction machinery by its association with CD3zeta and FcepsilonRIgamma adaptor proteins. NKp46 along with NKp30 and NKp44 are referred to as natural cytoxicity receptors (NCR) and play a very important role in killing virus-infected, tumor cells and MHC-class I-unprotected cells. This antibody is routinely tested by flow cytometric analysis.
    Pathways
    Regulation of Leukocyte Mediated Immunity
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