CD8 anticorps

N° du produit ABIN1177374

Cet anticorps anti-CD8 est un anticorps Souris Monoclonal détectant CD8 dans FACS. Adapté pour Humain.

Aperçu rapide pour CD8 anticorps (ABIN1177374)

Antigène: CD8

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD8 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: RPA-T8

Détail du produit anti-CD8 anticorps

Marque: BD Pharmingen™

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Isotype: IgG1 kappa

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Détails sur CD8

Antigène: CD8

Autre désignation: CD8

Sujet: The RPA-T8 monoclonal antibody specifically binds to CD8 alpha (CD8alpha). CD8alpha is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD8alpha is expressed by the majority of thymocytes, by subpopulations of alphabeta T cells and gammadelta T cells and by some NK cells. Cell surface CD8alpha is expressed either as a disulfide-linked homodimer (CD8alphaalpha) or as a heterodimer (CD8alphabeta) when disulfide-bonded to a CD8 beta chain (CD8beta). CD8-positive alphabeta T cells coexpress both CD8alphaalpha homodimers and CD8alphabeta heterodimers whereas some gammadelta T cells and NK cells express CD8alphaalpha homodimers. CD8 plays important roles in T cell activation and selection. The extracellular IgSF domain of CD8alpha binds to a non-polymorphic determinant on HLA class I molecules (alpha3 domain) and enables CD8 to function as a co-receptor with MHC class I-restricted TCR during T cell recognition of antigen. The cytoplasmic domain of CD8alpha associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling. The RPA-T8 and HIT8a (Cat. No. 555337) monoclonal antibodies are not cross-blocking.
Synonyms: CD8alpha, CD8A, CD8 alpha, Leu2, MAL, T8, p32