CD39 anticorps (PE)

N° du produit ABIN118627

Détail du produit anti-CD39 anticorps (PE)

Antigène: CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD39 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Specificité: This antibody binds to the Human CD39 cell surface antigen, a 70-100 kDa molecule expressed on peripheral blood B cells, monocytes and T cell clones. CD39 has intrinsic ecto-ATPase activity. Expression is induced on T cells and increased on B cells as a late activation antigen. This antibody has been shown to block MHC independent target cell recognition by hapten-specific CTL. SM1101A is recommended for this purpose (Ref.8).

Purification: Affinity Chromatography on Protein G.

Immunogène: PHA activated human lymphocytes

Clone: A1

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry: Use 10 μL of neat antibody to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This antibody has been shown to block MHC independent target cell recognition by hapten- specific CTL. ABIN118624 is recommended for this purpose (8).

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 1.0 mL distilled water.

Concentration: 0.1 mg/mL

Buffer: PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: This product is photosensitive and should be protected from light

Stock: 4 °C

Stockage commentaire: Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Détails sur CD39

Antigène: CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))

Autre désignation: CD39 / ENTPD1 (ENTPD1 Produits)

Synonymes: anticorps ATPDase, anticorps CD39, anticorps NTPDase-1, anticorps MGC80631, anticorps zgc:100819, anticorps entpd1, anticorps MGC79567, anticorps 2610206B08Rik, anticorps AA408691, anticorps Cd39, anticorps ectonucleoside triphosphate diphosphohydrolase 1, anticorps ectonucleoside triphosphate diphosphohydrolase 1 L homeolog, anticorps ENTPD1, anticorps Entpd1, anticorps entpd1.L, anticorps entpd1

Sujet: Human CD39 is found on most mature B cells, activated NK cells and activated T cells. CD39 is also weakly expressed on granulocytes. CD39 has homology to the Nmyc family of proteins and was recently cloned. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 transgenic mice exhibit impaired platelet aggregation, prolonged bleeding times, and resistance to systemic thromboembolism. There is a correlation between ATP hydrolysis and triglycerides in patients with chronic heart disease, suggesting a relationship between ATP diphosphohydrolase and thrombogenesis. Depolarization causes the endothelial production of superoxide, which inhibits the activity of endothelial CD39 and enhances platelet aggregation. After exercise, all subjects showed a significant reduction of CD39 expression in platelet and an increase of CD39 expression in B lymphocytes.Synonyms: ATPDase, Ecto-ATP diphosphohydrolase, Ecto-apyrase, Ectonucleoside triphosphate diphosphohydrolase 1, Lymphoid cell activation antigen, NTPDase 1

ID gène: 953

NCBI Accession: NP_001091645

UniProt: P49961