DAXX anticorps (C-Term)

N° du produit ABIN119584

Cet anticorps Souris Monoclonal détecte spécifiquement DAXX dans WB et IF. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour DAXX anticorps (C-Term) (ABIN119584)

Antigène: DAXX (Death-Domain Associated Protein (DAXX))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DAXX est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: DAXX-01

Détail du produit anti-DAXX anticorps

Épitope: AA 558-740, C-Term

Specificité: The antibody reacts with Daxx, a death domain containing protein mainly expressed in fetal and adult tissue.

Purification: Affinity Chromatography on Protein-A.

Immunogène: Recombinant C-terminal part (aa 558-740) of Human Daxx

Isotype: IgG1

Information d'application

Indications d'application: Western Blot. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.4 with 15 mM Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur DAXX

Antigène: DAXX (Death-Domain Associated Protein (DAXX))

Autre désignation: DAXX

Sujet: Daxx is an apoptosis-modulating death-domain associated protein with functions in transcriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).Synonyms: BING2, DAP6, Death domain-associated protein 6, EAP1, ETS1-associated protein 1, Fas death domain-associated protein

ID gène: 1616

NCBI Accession: NP_001135441

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway