IL-10RA anticorps

N° du produit ABIN119862

Détail du produit anti-IL-10RA anticorps

Antigène: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-10RA est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func)

Specificité: This antibody recognises CDw210a, a cell surface glycoprotein of approximately 110KD, also known as Interleukin-10 receptor 1 (IL-10R1). The epitope recognised by this antibody has been localised to the ligand binding domain within the extracellular region of Mouse CDw210a. The specificity of this antibody has been confirmed by blocking with excess IL-10. This clone is reported to neutralize the effects of IL-10 (1). Does not react with Human.

Purification: Affinity Chromatography on Protein G

Immunogène: Purified recombinant epitope tagged extracellular region of Mouse CDw210a (SMCD210-FLAG-His6). Spleen cells from immunised Fisher rats were fused with cells of the mouse SP2/0 myeloma cell line.

Clone: 1B1-3a

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry: 1/10 - 1/100, Use 10 μL of the suggested working dilution to label 1x 10^6 cells in 100 μL, Due to low expression of CD210, sensitive staining techniques may be required. Functional Assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 without preservatives

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody at -20 °C. Ship at 2 - 8 °C.

Détails sur IL-10RA

Antigène: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Autre désignation: CDw210a / IL10RA (IL10RA Produits)

Synonymes: anticorps IL10R1, anticorps IL10RA, anticorps CD210, anticorps CD210a, anticorps CDW210A, anticorps HIL-10R, anticorps IL-10R1, anticorps IL10R, anticorps AW553859, anticorps CDw210, anticorps CDw210a, anticorps Il10r, anticorps mIL-10R, anticorps interleukin 10 receptor subunit alpha, anticorps interleukin 10 receptor, alpha, anticorps IL10RA, anticorps Il10ra

Sujet: Interleukin 10 binds specifically and with high affinity to cell-surface receptors. Interleukin 10 receptors are members of the class II subgroup of the cytokine receptor superfamily. The IL10 receptor complex contains two distinct type II cytokine receptor subunits, the ligand binding IL10RA and the IL10RB. The coexpression of both chains is essential for IL10 induced signal transduction. The beta chain serves as an accessory chain essential for the active IL10 receptor complex and necessary for the initiation of signal transdunction. Interleukin 10 receptors are expressed in all cell types that are known to respond to IL10. Mouse CDw210a is expressed by a range of cells including thymocytes, T cells, B cells and monocytes.Synonyms: IL-10R-A, IL10 Receptor alpha, Interleukin-10 receptor alpha chain

ID gène: 16154

NCBI Accession: NP_032374

UniProt: Q61727

Pathways: Growth Factor Binding