SIT1 anticorps

N° du produit ABIN120658

Détail du produit anti-SIT1 anticorps

Antigène: SIT1 (Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SIT1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS)

Specificité: The antibody reacts with SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs.

Attributs du produit: Synonyms: Signaling threshold-regulating transmembrane adapter 1, SHP2-interacting transmembraneadapter protein, Suppression-inducing transmembrane adapter 1

Purification: Protein-A affinity chromatography

Pureté: > 95 % pure (by SDS-PAGE)

Immunogène: Bacterially produced recombinant intracellular fragment of human SIT.

Clone: SIT-01

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry (intracellular staining). Immunoprecipitation. Western Blotting: Western blot analysis demonstrated that SIT is expressed as anapproximately 40 kDa protein that is reduced to approximately 20 kDa by endoglycosidasetreatment.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur SIT1

Antigène: SIT1 (Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1))

Autre désignation: SIT1 / SIT (SIT1 Produits)

Synonymes: anticorps SIT1, anticorps RP11-331F9.5, anticorps SIT, anticorps SIT-R, anticorps Sit, anticorps signaling threshold regulating transmembrane adaptor 1, anticorps suppression inducing transmembrane adaptor 1, anticorps SIT1, anticorps Sit1

Sujet: SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.Synonyms: SHP2-interacting transmembrane adapter protein, Signaling threshold-regulating transmembrane adapter 1, Suppression-inducing transmembrane adapter 1

ID gène: 27240

UniProt: Q9Y3P8