CD8 anticorps (FITC)

N° du produit ABIN120695

L’anticorps Souris Monoclonal anti-CD8 a été validé pour FACS. Il convient pour détecter CD8 dans des échantillons de Humain.

Aperçu rapide pour CD8 anticorps (FITC) (ABIN120695)

Antigène: CD8

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD8 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Clone: MEM-31

Détail du produit anti-CD8 anticorps (FITC)

Specificité: The antibody recognizes a conformationally-dependent epitope of CD8 antigen (does not react with formaldehyde-fixed cells, negative in Western Blotting application).

Réactivité croisée (Details): Species reactivity (tested):Human.

Attributs du produit: Synonyms: T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain

Immunogène: Crude thymus membrane fraction.

Isotype: IgG2a

Information d'application

Indications d'application: Flow Cytometry: Human blood cells using 20 μL reagent / 100 μL whole blood or 10^6 cellsin a suspension. Does not work in Immunohistochemistry on formalin fixed cells or Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline (PBS) containing 15 mM Sodium Azide and 0.2 % (w/v) high-grade protease free BSA as a stabilizing agent.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody at 2-8 °C. DO NOT FREEZE. This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CD8

Antigène: CD8

Autre désignation: CD8

Sujet: The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as ab heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as aa homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8b level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 a-b but not a-a dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2

ID gène: 925

UniProt: P01732