CD8 anticorps

N° du produit ABIN120696

Cet anticorps anti-CD8 est un anticorps Souris Monoclonal détectant CD8 dans FACS et IP. Adapté pour Humain.

Aperçu rapide pour CD8 anticorps (ABIN120696)

Antigène: CD8

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD8 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: MEM-31

Détail du produit anti-CD8 anticorps

Specificité: The antibody recognizes a conformationally-dependent epitope of CD8 antigen.

Attributs du produit: Synonyms: T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain

Purification: Protein-A affinity chromatography

Pureté: > 95 % pure (by SDS-PAGE)

Immunogène: Crude thymus membrane fraction.

Isotype: IgG2a

Information d'application

Indications d'application: Flow Cytometry. Immunoprecipitation. Does not work in Western blot or Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4-8 °C for one month or at -20 °C for longer. Avoid repeated freezingand thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CD8

Antigène: CD8

Autre désignation: CD8

Sujet: The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as ab heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as aa homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8b level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 a-b but not a-a dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2

ID gène: 925

UniProt: P01732