CD8 anticorps (PE)

N° du produit ABIN120697

Cet anticorps Souris Monoclonal détecte spécifiquement CD8 dans FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour CD8 anticorps (PE) (ABIN120697)

Antigène: CD8

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD8 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Clone: MEM-31

Détail du produit anti-CD8 anticorps (PE)

Specificité: The antibody recognizes a conformationally-dependent epitope of CD8 antigen.

Attributs du produit: Synonyms: T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain

Immunogène: Crude thymus membrane fraction.

Isotype: IgG2a

Information d'application

Indications d'application: Flow Cytometry analysis of human blood cells using 20 l reagent / 100 l whole blood or10^6 cells in a suspension. Does not work in Immunohistocchemistry omn paraffin sections or Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Stock: 4 °C

Stockage commentaire: Store at 2-8 °C. Do not freeze. Avoid prolonged exposure to light.
Shelf life: one year fromdespatch.

Date de péremption: 12 months

Détails sur CD8

Antigène: CD8

Autre désignation: CD8

Sujet: The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as ab heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as aa homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8b level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 a-b but not a-a dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2

ID gène: 925

UniProt: P01732