CXCR3 anticorps (C-Term)

N° du produit ABIN121951

Cet anticorps Lapin Polyclonal détecte spécifiquement CXCR3 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CXCR3 anticorps (C-Term) (ABIN121951)

Antigène: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CXCR3 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CXCR3 anticorps

Épitope: C-Term

Specificité: Recognizes Human CXC Chemokine Receptor type 3 (Family: GPCR, Subfamily: Chemokine). BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except SRRM2 (59 %).

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogène: Synthetic peptide - KLH conjugated.

Information d'application

Indications d'application: Immunohistochemistry on paraffin embedded sections: 16 μg/mL. Antigen Retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 to -70 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CXCR3

Antigène: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Autre désignation: CD183 / CXCR3

Sujet: CXCR3, a Chemokine Receptor, is highly similar to the interleukine 8B receptor and has been shown to mediate recruitment of T cells to sites of inflammation and retention of T-cells in the inflamed CNS. CXCR3 has been suggested to be the principal inflammatory chemokine receptor involved in intrathecal accumulation of T-cells in multiple sclerosis and diabetes. It is expressed on malignant B cells in chronic lymphoproliferative disorders (Jones et al., 2000). Ligand: Interferon gamma-inducible protein 9, Interferon gamma-inducible protein 10 and Interferon gamma inducible CXC chemokines I-TAC, IP10 and Mig. An alternatively spliced isoform, CXCR3B, has recently been identified (Lasagni et al. 2003). CXCR3 expression has been documented in the brain, lymphoid and other peripheral tissues, and in diseasess including atheroslerosis, Alzheimer's, multiple sclerosis, rheumatoid arthritis, lymphomas, asthma, neoplasms, leukemia, and inflammatory conditions of various organs.Synonyms: CXC-R3, CXCR-3, G protein-coupled receptor 9, GPR9, IP-10 receptor, IP10 receptor, Interferon-inducible protein 10 receptor

ID gène: 2833

UniProt: P49682