BDKRB1 anticorps (Cytoplasmic Domain)

N° du produit ABIN122013

Cet anticorps anti-BDKRB1 est un anticorps Lapin Polyclonal détectant BDKRB1 dans IHC (p). Adapté pour Humain, Rat et Souris.

Aperçu rapide pour BDKRB1 anticorps (Cytoplasmic Domain) (ABIN122013)

Antigène: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BDKRB1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-BDKRB1 anticorps

Épitope: Cytoplasmic Domain

Specificité: Reacts with Bradykinin B1 Receptor 1 (family: GPCR, subfamily:Bradykinin)

Réactivité croisée (Details): Species reactivity (expected):Mouse and RatSpecies reactivity (tested):Human

Purification: Immunoaffinity Chromatography.

Immunogène: Synthetic peptide - KLH conjugated

Information d'application

Indications d'application: Immunohistochemistry with formalin fixed paraffin embedded tissues: 5-9 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or(in aliquots) at -20 °C to -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur BDKRB1

Antigène: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Autre désignation: BDKRB1

Sujet: Bradykinin Receptor B1 (BKB1) has been implicated in inflammation and nociception. BKB1 receptor is rapidly induced under many inflammatory conditions such as colitis and hyperalgesia, allergic rhinitis, and inflammation. In vitro studies have implicated lipopolysaccharide, interleukins, and interferon as effectors in the rapid induction of BKB1 receptor expression. BKB1 receptor-deficient mice are healthy, fertile, and normotensive but show blunted response to lipopolysaccharide-induced hypotension, reduced migration into inflamed tissues by polymorphonuclear leukocytes, and reduced activity-dependent facilitation of a spinal nociceptive reflex. Bradykinin B1 receptor is generally only minimally expressed under normal physiological conditions, but the expression is induced rapidly under pathologic conditions such as ischemia, atheromatous disease, or exposure to inflammatory cytokines. Expression has been reported in brain, colon, kidney, lung, nasal mucosa, pancreas, prostate, skin, spinal cord, and vessel. ESTs have been isolated from normal human connective tissue libraries and in human kidney and skin cancer libraries.Synonyms: B1 bradykinin receptor, B1R, BK-1 receptor, BKB1R, BKR1, BRADYB1, Bradykinin B1 Receptor

ID gène: 623

UniProt: P46663

Pathways: ACE Inhibitor Pathway