CALCRL anticorps (Cytoplasmic Domain)

N° du produit ABIN122018

L’anticorps Lapin Polyclonal anti-CALCRL a été validé pour IHC (p). Il convient pour détecter CALCRL dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CALCRL anticorps (Cytoplasmic Domain) (ABIN122018)

Antigène: CALCRL (Calcitonin Receptor-Like (CALCRL))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CALCRL est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CALCRL anticorps

Épitope: Cytoplasmic Domain

Specificité: Reacts with Calcitonin Receptor-Like Receptor (Family: GPCR, subfamily: Adrenomedullin). BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except CALCR (56 %).

Réactivité croisée (Details): Species reactivity (expected):Mouse (93 % identity and similarity) and Rat (100 % identity and similarity).
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogène: Synthetic peptide - KLH conjugated

Information d'application

Indications d'application: Immunohistochemistry with formalin fixed paraffin embedded tissues: 34 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CALCRL

Antigène: CALCRL (Calcitonin Receptor-Like (CALCRL))

Autre désignation: CGRP Type 1 Receptor / CRLR

Sujet: Calcitonin receptor-like receptor (CRLR) is an Adrenomedullin Receptor that requires two additional proteins to function: a chaperone protein RAMP (receptor activity modifying protein) and the component protein RCP. The function of CRLR depends on its interaction with RAMP. When coexpressed with RAMP1, CRLR acts as a receptor for calcitonin gene-related peptide (CGRP). In contrast, when CRLR is coexpressed with either RAMP2 or RAMP3, it acts as a receptor for adrenomedullin. Activation of the receptor leads to an increase in intracellular cyclic AMP. CRLR mediates the vasorelaxation of arteries, suggesting a potential role for the receptor in reaction to injury, particularly in the treatment of pulmonary hypertension. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries.Synonyms: CALCRL, CGRPR, Calcitonin gene-related peptide type 1 receptor, Calcitonin receptor-like receptor

ID gène: 10203

UniProt: Q16602

Pathways: cAMP Metabolic Process