CysLTR1 anticorps (3rd Extracellular Domain)

N° du produit ABIN122043

Cet anticorps anti-CysLTR1 est un anticorps Lapin Polyclonal détectant CysLTR1 dans IHC (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour CysLTR1 anticorps (3rd Extracellular Domain) (ABIN122043)

Antigène: CysLTR1 (CYSLTR1) (Cysteinyl Leukotriene Receptor 1 (CYSLTR1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CysLTR1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CysLTR1 anticorps

Épitope: 3rd Extracellular Domain

Specificité: Reacts with Cysteinyl Leukotriene Receptor 1(Family: GPCR, Subfamily: Chemoattractant).

Attributs du produit: Synonyms: Cysteinyl leukotriene receptor 1, CysLTR1, LTD4 receptor, HG55, HMTMF81, Cysteinylleukotriene D4 receptor, G-protein coupled receptor HG55

Purification: Peptide immunogen affinity column

Immunogène: Synthetic peptide - KLH conjugatedEpitope: 3rd extracellular domain of humanGenename: CYSLTR1Remarks: The immunizing peptide shows 80 % identity (85 % similarity) with mouse and75 % identity (90 % similarity) with rat.

Information d'application

Indications d'application: Immunohistochemistry with formalin fixed paraffin embedded tissues: 6 -14g/mL. Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove fromheat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween(TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, containing 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-80 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CysLTR1

Antigène: CysLTR1 (CYSLTR1) (Cysteinyl Leukotriene Receptor 1 (CYSLTR1))

Autre désignation: CYSLTR1

Sujet: Cysteinyl leukotriene receptor 1, a Chemoattractant Receptor, is detected in spleen, peripheral blood leukocytes, and lung smooth muscle (Lynch et al., 1999). It binds cysteinyl leukotrienes, which are neutrophil chemoattractants with potent proinflammatory action. Leukotrienes mediate many features of bronchial asthma such as edema, bronchial constriction, and hyperreactivity (Bisgaard et al., 2000). Selective CysLT1 antagonists are used to treat asthma. The cysteinyl leukotrienes, leukotriene C4 (LTC4), leukotriene D4 (LTD4), and leukotriene E4 (LTE4) activate at least two receptors, CysLT1 and CysLT2, to mediate human bronchial asthma. LTC(4), LTD(4), and LTE(4) are a class of peptide-conjugated lipids formed from arachidonic acid and that are released during activation of mast cells.Synonyms: CysLTR1, Cysteinyl leukotriene D4 receptor, Cysteinyl leukotriene receptor 1, G-protein coupled receptor HG55, HG55, HMTMF81, LTD4 receptor

ID gène: 10800

UniProt: Q9Y271