LRP1 anticorps

N° du produit ABIN125951

L’anticorps anti-LRP1 Monoclonal Souris est utilisé pour la détection de LRP1 dans des échantillons de Humain, Souris, Rat, Lapin et Hamster. Il a été validé pour WB, FACS, IF et IHC (fro).

Aperçu rapide pour LRP1 anticorps (ABIN125951)

Antigène: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Reactivité: Humain, Souris, Rat, Lapin, Hamster

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LRP1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 5A6

Détail du produit anti-LRP1 anticorps

Specificité: This monoclonal antibody 5A6 specifically reacts with the 85 kDa beta-chain of LRP/alpha2MR which is expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurones and astrocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in atherosclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelomonocytic subtypes of chronic and acute leukemia (CD 91). Cross-reacts with rabbit LDL receptor-related protein (LRP) or mouse LRP.

Purification: Affinity Chromatography on Protein A.

Immunogène: Human LRP/alpha2MR.

Isotype: IgG2b

Information d'application

Indications d'application: Immunofluorescence. Immunohistochemistry on Frozen Sections (Dilute 1/20). Flow Cytometry. Immunoblotting. Neutralizing effects of 5A6 have also been reported (cf. Basu et al. , 2001).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in 1 mL dist. water

Buffer: Final solution contains 0.5 % BSA in PBS buffer, pH 7.4

Précaution d'utilisation: Do Not Add Sodium Azide

Conseil sur la manipulation: Avoid repeated freezing and thawing. Dilute only prior to immediate use

Stock: 4 °C/-20 °C

Stockage commentaire: Store vial at 2-8 °C prior to restoration. For extended storage add glycerol to 50% and then aliquot contents and freeze at -20 °C or below. Centrifuge product if not completely clear after standing at room temperature. This antibody is stable for one month at 2-8 °C as an undiluted liquid.

Détails sur LRP1

Antigène: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Autre désignation: CD91 / LRP1

Sujet: Synonyms: A2MR, APOER, APR, Alpha-2-macroglobulin receptor, Apolipoprotein E receptor, Prolow-density lipoprotein receptor-related protein 1

ID gène: 4035

NCBI Accession: NP_002323

UniProt: Q07954

Pathways: Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling