LRP1 anticorps

N° du produit ABIN125957

L’anticorps Souris Monoclonal anti-LRP1 a été validé pour WB, FACS, IF et IHC (fro). Il convient pour détecter LRP1 dans des échantillons de Humain, Souris, Rat, Lapin et Hamster.

Aperçu rapide pour LRP1 anticorps (ABIN125957)

Antigène: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Reactivité: Humain, Souris, Rat, Lapin, Hamster

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LRP1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 8B8

Détail du produit anti-LRP1 anticorps

Specificité: 8B8 specifically reacts with the 85 kDa β-chain of human LRP/α2MR which is expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepato-cytes, tissue macrophages, subsets of neurones and as-trocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in athero-sclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91).

Purification: Affinity Chromatography on Protein A.

Immunogène: Human LRP/alpha2MR

Isotype: IgG1

Information d'application

Indications d'application: Immunofluorescence. Immunohistochemistry: 1/20. Flow Cytometry. Immunoblotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in 1 mL dist. water.

Buffer: Final Solution contains PBS buffer, pH 7.4 containing 0.5 % BSA without preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: This product is photosensitive and should be protected from light

Stock: 4 °C

Stockage commentaire: Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Détails sur LRP1

Antigène: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Autre désignation: CD91 / LRP1

Sujet: Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.Synonyms: A2MR, APOER, APR, Alpha-2-macroglobulin receptor, Apolipoprotein E receptor, Prolow-density lipoprotein receptor-related protein 1

ID gène: 4035

NCBI Accession: NP_002323

UniProt: Q07954

Pathways: Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling