Cathepsin B anticorps
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- Antigène Voir toutes Cathepsin B (CTSB) Anticorps
- Cathepsin B (CTSB)
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Cathepsin B est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- The purified antibody detects both the proform (37-43 kDa) and the mature form (25 kDa) of Cathepsin B.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, Mouse and Rat.
- Purification
- Affinity Chromatography.
- Immunogène
- Synthetic peptide surrounding amino acid 322 of human cathepsins B
- Top Product
- Discover our top product CTSB Anticorps primaire
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- Indications d'application
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Western Blot: 0.5-4 μg/mL. Immunohistochemistry: 10-20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0.2 mg/mL
- Buffer
- PBS, pH 7.2 containing 30 % Glycerol, 0.5 % BSA and 0.01 % Thimerosal.
- Agent conservateur
- Thimerosal (Merthiolate)
- Précaution d'utilisation
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C/-80 °C
- Stockage commentaire
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -20 °C to -70 °C.
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- Antigène
- Cathepsin B (CTSB)
- Autre désignation
- Cathepsin B (CTSB Produits)
- Synonymes
- anticorps APPS, anticorps CPSB, anticorps CB, anticorps apps, anticorps cpsb, anticorps LOC692390, anticorps CTSB, anticorps cathepsin B, anticorps cathepsin B S homeolog, anticorps CTSB, anticorps Ctsb, anticorps ctsb.S, anticorps LOC692390
- Sujet
- Cathepsin B is a normal lysosomal cysteine proteinase that is expressed in all cells. It is synthesized as an inactive 43 kDa pro-enzyme which, by removal of a 62 amino acid propeptide, is activated to the single-chain form of 31 kDa or the two-chain form (25 and 5 kDa subunits). Matured cathepsin B is normally localized in the lysosomes where it functions in protein turnover. Cathepsin B is also shown capable of degrading extracellular matrix proteins. Elevated levels of cathepsin B correlate with malignancy suggesting that this enzyme may be a useful prognostic marker for several types of human cancers.Synonyms: APP secretase, APPS, CPSB, CTSB, Cathepsin B1
- ID gène
- 1508
- NCBI Accession
- NP_001899
- UniProt
- P07858
- Pathways
- Activation of Innate immune Response, Toll-Like Receptors Cascades
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