CD24 anticorps

N° du produit ABIN135358

Détail du produit anti-CD24 anticorps

Antigène: CD24 (CD24 Molecule (CD24))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD24 est non-conjugé

Application: Flow Cytometry (FACS)

Specificité: Mouse CD24, Mr 35-45 kDa

Attributs du produit: Rat Anti-Mouse CD24-UNLB

Purification: Purified

Immunogène: Mouse thymus or spleen

Clone: 30-F1

Isotype: IgG2c

Information d'application

Indications d'application:

• Applications: FC - Quality tested
• Working Dilutions: Flow Cytometry FITC and BIOT conjugates 2 g/106 cells PE, APC, and SPRD conjugates 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Volume d'échantillon: 1 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Détails sur CD24

Antigène: CD24 (CD24 Molecule (CD24))

Autre désignation: CD24 (CD24 Produits)

Synonymes: anticorps CD24A, anticorps Cd24a, anticorps CD24 molecule, anticorps CD24, anticorps Cd24

Sujet: CD24 is expressed in B cells until their terminal differentiation into plasma cells. It has been used widely as a marker to fractionate different B-lineage differentiation stages. CD24 has been found on a variety of other hematopoietic and neural cell types, and is now classified as a costimulatory molecule. The CD24/HSA molecule is composed mostly of carbohydrate, with a protein core of only 31-35 amino acids in the human and 27 AA in the mouse. The molecular mass is variable, ranging from 38-70 kDa. CD24 is now included in the large group of phosphatidylinositol-anchored membrane proteins. Studies with purified CD24 applied to latex beads have demonstrated a self-binding property, suggesting that the molecule is capable of promoting homotypic aggregation, binding and cell adhesion. This is supported by earlier observations of the blockade of B cell lymphoblast aggregation with anti-CD24 monoclonal antibody. Recent studies of murine CD24 have assigned a role for CD24/HSA as a ligand for P-selectin, a calcium-dependent lectin.

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation