UBXN6 anticorps

N° du produit ABIN1381742

L’anticorps Souris Monoclonal anti-UBXN6 a été validé pour WB, IF et IP. Il convient pour détecter UBXN6 dans des échantillons de Humain et Souris.

Aperçu rapide pour UBXN6 anticorps (ABIN1381742)

Antigène: UBXN6 (UBX Domain Protein 6 (UBXN6))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp UBXN6 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 2F8-24

Détail du produit anti-UBXN6 anticorps

Specificité: Detects only full length isoform

Réactivité croisée: Souris

Purification: purified

Immunogène: recombinant protein purified from bacteria

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.5 % PBS, 50 % glycerol, 0.1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C

Stockage commentaire: short term: 2 °C - 8 °C, long term: -20 °C

Détails sur UBXN6

Antigène: UBXN6 (UBX Domain Protein 6 (UBXN6))

Autre désignation: UBXD1 (Full Length Isoform)

Sujet: P97 is a highly abundant and conserved member of the AAA family of ATPase. It has been termed an ubiquitin selective chaperone as it functions within the ubiquitin and/or proteasome pathway. p97 does not interact with ubiquitinated substrates on its own, but requires specific adapters that interact with ubiquitinated substrates and p97 and recruits p97 to substrates. One family of adapters contains a UBX domain, which has been shown with certain adapters to function as a p97-binding module. UBXD1 is a UBX domain containing protein and p97 adapter. This adapter is unique in that it does not harbor an ubiquitin association domain and binds p97 via its PUG domain (another p97 binding motif). Two isoforms of UBXD1 are produced in cells, a full-length form of approximately 54 kDa, and an alternatively spliced variant that lacks the amino-terminal translational start site, and encodes a 47 kDa protein that is derived from an internal translational initiation site. UBXD1 expression at the RNA level has been shown to trend lower in poor prognostic cancers, including those of the breast and prostate.

UniProt: Q9BZV1