CECR1 anticorps (AA 450-500)

N° du produit ABIN1385331

Cet anticorps anti-CECR1 est un anticorps Lapin Polyclonal détectant CECR1 dans FACS, IHC (p) et IF (p). Adapté pour Humain.

Aperçu rapide pour CECR1 anticorps (AA 450-500) (ABIN1385331)

Antigène: CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CECR1 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-CECR1 anticorps

Épitope: AA 450-500

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CECR1/ADGF

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur CECR1

Antigène: CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1))

Autre désignation: CECR1

Sujet:

Synonyms: ADGF, Cat eye syndrome chromosome region candidate 1, Cat eye syndrome critical region protein 1, Cat eye syndrome critical region protein 1 precursor, CECR 1, IDGFL, CECR1_HUMAN.

Background: CECR1 is a member of the adenosine and AMP deaminases family. It may act as a growth factor and have adenosine deaminase activity. It is a candidate gene for cat eye syndrome. Two transcript variants encoding distinct isoforms have been identified for this gene.Adenosine deaminase is an enzyme that is present in most tissues and exists predominantly as a monomer, although in some tissues it is associated with adenosine deaminase-binding protein. Adenosine deaminase degrades extracellular adenosine, which is toxic for lymphocytes. A novel family of growth factors that share sequence similarity to adenosine deaminase has been identified. The cat eye syndrome critical region protein (CECR) family includes CECR1, CECR2, CECR3, CECR4, CECR5, CECR6, CECR7, CECR8 and CECR9. The genes encoding CECR proteins are candidates for Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. CES is characterized by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development. CECR family members are widely expressed. Specifically, CECR1 has the highest expression in adult heart, lung, lymphoblasts and placenta. CECR2 is also involved in neurulation and chromatin remodeling. Mutations in the CECR2 gene result in neural tube defects.

ID gène: 51816

UniProt: Q9NZK5

Pathways: Ribonucleoside Biosynthetic Process