Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2) (AA 401-497) anticorps

N° du produit ABIN1385561

Détail du produit

Antigène: Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2)

Épitope: AA 401-497

Reactivité: Humain, Virus

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Virus

Réactivité croisée (Details): HHV4t2

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from HHV4t2 LMP2

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2)

Autre désignation: EBV LMP2

Classe de substances: Viral Protein

Sujet:

Synonyms: EBV latent membrane protein 2A, Epstein Barr virus, HHV4, Human Herpesvirus 4, Latent membrane protein 2, LMP2, Terminal protein, EBV LMP2A, LMP2_EBVB9 , Latent membrane protein 2B, EBV LMP2B.

Background: Epstein Barr virus (EBV) is a member of the herpesvirus family and one of the most common human viruses. Most people become infected with EBV during their lives. Primary infections usually results in infectious mononucleosis (glandular fever) but the virus can also lay dormant in B lymphocytes and when reactivated become associated with more serious disease such as Burkitt's lymphoma, nasopharyngeal carcinoma and Hodgkin's disease. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.