ALAS2 anticorps

N° du produit ABIN1385780

Détail du produit anti-ALAS2 anticorps

Antigène: ALAS2 (Aminolevulinate, delta-, Synthase 2 (ALAS2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALAS2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ALAS2/ALAS-E

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur ALAS2

Antigène: ALAS2 (Aminolevulinate, delta-, Synthase 2 (ALAS2))

Autre désignation: ALAS-E (ALAS2 Produits)

Synonymes: anticorps anh1, anticorps asb, anticorps xlsa, anticorps ALAS-E, anticorps ALASE, anticorps ANH1, anticorps ASB, anticorps XLDPP, anticorps XLEPP, anticorps XLSA, anticorps alas-e, anticorps cb1063, anticorps sau, anticorps sauternes, anticorps ALAS, anticorps Alas-2, anticorps 5'-aminolevulinate synthase 2, anticorps aminolevulinate, delta-, synthase 2, anticorps aminolevulinic acid synthase 2, erythroid, anticorps alas2, anticorps ALAS2, anticorps Alas2, anticorps alas2.L

Sujet:

Synonyms: 5-aminolevulinate synthase, erythroid-specic, mitochondrial, 5-aminolevulinic acid synthase, ALAS E, ALASE, ANH1, Delta aminolevulinate synthase, XLSA, 5 aminolevulinic acid synthase 2, 5-aminolevulinate synthase 2, 5-aminolevulinate synthase, 5-aminolevulinate synthase 2, Alas 2, ALAS, ALAS E, ALAS, erythroid, ALASE, Aminolevulinate, delta-, synthase 2, Aminolevulinic acid synthase 2, erythroid, ANH1, ASB, Delta ALA synthase 2, Delta ALA synthetase, Delta aminolevulinate synthase 2, Delta aminolevulinate synthase, Erythroid specic ALAS, FLJ93603, XLDPP, XLSA.

Background: 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.

ID gène: 212

Pathways: Transition Metal Ion Homeostasis