Hippocalcin anticorps (AA 101-193)

N° du produit ABIN1385803

Cet anticorps Lapin Polyclonal détecte spécifiquement Hippocalcin dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Hippocalcin anticorps (AA 101-193) (ABIN1385803)

Antigène: Hippocalcin (HPCA)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Hippocalcin est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Hippocalcin anticorps

Épitope: AA 101-193

Fonction: Hippocalcin Polyclonal Antibody

Réactivité croisée: Souris, Rat

Homologie: Human,Cow,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Hippocalcin

Isotype: IgG

Information d'application

Indications d'application: WB(1:300-5000)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Hippocalcin

Antigène: Hippocalcin (HPCA)

Autre désignation: Hippocalcin

Sujet:

Synonyms: BDR 2, BDR2, Calcium binding protein BDR 2, Calcium binding protein BDR2, Calcium-binding protein BDR-2, Hpca, HPCA_HUMAN, Neuron specic calcium binding protein hippocalcin, Neuron specic calcium-binding protein hippocalcin, Neuron-specic calcium-binding protein hippocalcin,P23K.

Background: Hippocalcin is a neuron-specific calcium-binding protein found primarily in the plasma membrane of brain and retinal tissue, with increased expression observed in hippocampal pyramidal cells. Through its calcium-dependent signal regulation, hippocalcin can both inhibit rhodopsin kinase and increase phospholipase D2 expression. In order to regulate kinase and phospholipase activity, hippocalcin must bind to the plasma membrane where it can then bind two calcium ions for use in signal regulation. The hippocalcin protein is highly conserved in mouse, rat and human tissue and has a suggested role in neural plasticity and associative memory by contributing to the survival of neurons during aging. The loss of hippocalcin expression is thought to contribute to age-related impairment of post-synaptic functions related to neuronal degradation.