LIM Domain Binding 1 Protein anticorps (AA 10-100)

N° du produit ABIN1386034

Détail du produit anti-LIM Domain Binding 1 Protein anticorps

Antigène: LIM Domain Binding 1 Protein (LDB1) (LIM Domain Binding 1 (LDB1))

Épitope: AA 10-100

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LIM Domain Binding 1 Protein est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human LDB1/CLIM-2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur LIM Domain Binding 1 Protein

Antigène: LIM Domain Binding 1 Protein (LDB1) (LIM Domain Binding 1 (LDB1))

Autre désignation: LDB1/CLIM-2 (LDB1 Produits)

Synonymes: anticorps CLIM2, anticorps NLI, anticorps chi, anticorps clim2, anticorps nli, anticorps xldb1, anticorps ldb1, anticorps LDB1, anticorps ldb4, anticorps ldb4b, anticorps LIM domain binding 1, anticorps LIM domain binding 1 L homeolog, anticorps LIM-domain binding 1b, anticorps LIM domain binding protein 1, anticorps LIM domain binding 1a, anticorps Ldb1, anticorps LDB1, anticorps ldb1.L, anticorps ldb1b, anticorps xldb1, anticorps ldb1a

Sujet:

Synonyms: Carboxyl Terminal LIM Domain Binding 2, Carboxyl-terminal LIM domain-binding protein 2, CLIM 2, CLIM-2, hLdb1, LDB-1, ldb1, LDB1_HUMAN, LIM Domain Binding 1, LIM domain binding factor CLIM2, LIM domain-binding factor CLIM2, LIM domain-binding protein 1, NLI, Nuclear LIM Domain Interactor, Nuclear LIM interactor antibodyxldb1.

Background: The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterized by a conserved LIM domain. The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation. LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons. LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI). NLI, known also as CLIM-1, and the related protein CLIM-2, facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins. LMO2 and the related protein LMO4 are expressed in thymic precursor cells. LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors.

Pathways: Stem Cell Maintenance, Chromatin Binding