HSD17B4 anticorps (AA 521-620)

N° du produit ABIN1386308

L’anticorps Lapin Polyclonal anti-HSD17B4 a été validé pour WB, ELISA, IHC (p), IF (cc), IF (p), ICC et IHC (fro). Il convient pour détecter HSD17B4 dans des échantillons de Souris, Mouton et Poisson zèbre (Danio rerio). Il y a 1 publication disponible.

Aperçu rapide pour HSD17B4 anticorps (AA 521-620) (ABIN1386308)

Antigène: HSD17B4 (Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4))

Reactivité: Souris, Mouton, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD17B4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-HSD17B4 anticorps

Épitope: AA 521-620

Réactivité croisée: Souris, Mouton, Poisson zèbre (Danio rerio)

Homologie: Human,Rat,Cow,Pig,Horse,Chicken,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HSD17B4 Enoyl-CoA hydratase 2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-HSD17B4 (ABIN1386308)

Zhang, Zhao, Zhang, Hao, Yu, Min, Li, Ma, Chen, Yi, Tang, Meng, Liu, Wang, Shen, Zhang: "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." dans: Chemosphere, Vol. 194, pp. 147-157, (2018) (PubMed).

Détails sur HSD17B4

Antigène: HSD17B4 (Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4))

Autre désignation: HSD17B4

Sujet:

Synonyms: hydroxysteroid 17-beta dehydrogenase 4, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase, 17 beta HSD 4, 17 beta HSD IV, 17 beta hydroxysteroid dehydrogenase 4, 17-beta-HSD 4, 17-beta-hydroxysteroid dehydrogenase 4, 17beta estradiol dehydrogenase type IV, 3 alpha 7 alpha12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase antibody 3-alpha, 7-alpha, Beta hydroxyacyl dehydrogenase, Beta keto reductase, D 3 hydroxyacyl CoA dehydratase, D bunctional protein, D bunctional protein peroxisomal, D-bunctional protein, DBP, DHB4_HUMAN, EDH17B4, Enoyl-CoA hydratase 2, Hsd17b4, MFE 2, MFE-2, MPF-2, Multunctional protein 2, Peroxisomal multunctional enzyme type 2, Peroxisomal multunctional protein 2, SDR8C1, Short chain dehydrogenase/reductase family 8C member 1.

Background: 17Beta-HSD4 (17Beta-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-Beta Estradiol dehydrogenase type IV. It belongs to the 17Beta-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17Beta-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol Beta-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17Beta-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17Beta-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.

Pathways: Monocarboxylic Acid Catabolic Process