CASK anticorps (AA 651-750)

N° du produit ABIN1386520

Cet anticorps Lapin Polyclonal détecte spécifiquement CASK dans ELISA, IF (cc), IF (p), IHC (p), ICC et IHC (fro). Il présente une réactivité avec des échantillons de Rat.

Aperçu rapide pour CASK anticorps (AA 651-750) (ABIN1386520)

Antigène: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CASK est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-CASK anticorps

Épitope: AA 651-750

Réactivité croisée: Rat

Homologie: Human,Mouse,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CASK

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur CASK

Antigène: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Autre désignation: CASK

Sujet:

Synonyms: CAGH39, Caki, Calcium/calmodulin dependent serine protein kinase, Calcium/calmodulin dependent serine protein kinase MAGUK family, Calcium/calmodulin dependent serine protein kinase membrane associated guanylate kinase, Calcium/calmodulin-dependent serine protein kinase, CAMGUK, CAMGUK protein, CAMGUK, drosophila, homolog of antibody casK, CMG, CSKP_HUMAN, DXPri1, DXRib1, FGS4, hCASK, LIN 2, Lin 2 homolog, LIN2 antibody Lin2 homolog, MICPCH, MRXSNA, Pals3, Peripheral plasma membrane protein CASK, Protein lin-2 homolog, TNRC8, Trinucleotide repeat containing 8, Vertebtate LIN2 homolog.

Background: The MAGUK (membrane-associated guanylate kinase homologs) family of proteins contain multiple protein-binding domains and are involved in cell junction organization, tumor suppression, and signaling. CASK (also designated LIN-2) belongs to a MAGUK subfamily which is characterized by a novel domain structure that consists of a calcium/calmodulin- dependent protein kinase domain followed by PDZ, SH3 and guanylate kinase-like (GUK) domains. CASK is expressed in rat brain where it binds to cell-surface proteins, such as neurexin and syndecan, and is thought to be involved in signaling at neuronal synapses. CASK translocates to the nucleus and interacts with Tbr-1 to form a complex, which binds to a specific DNA sequence (the T-element), and induces the expression of specific genes, including Reelin. CASK displays a transcription regulation function, which appears crucial for cerebrocortical development.

Pathways: Synaptic Vesicle Exocytosis