ZFPM2 anticorps (AA 701-800)

N° du produit ABIN1386622

Cet anticorps Lapin Polyclonal détecte spécifiquement ZFPM2 dans WB, ELISA, IHC (p), ICC, IF (cc), IF (p) et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour ZFPM2 anticorps (AA 701-800) (ABIN1386622)

Antigène: ZFPM2 (Zinc Finger Protein, FOG Family Member 2 (ZFPM2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZFPM2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-ZFPM2 anticorps

Épitope: AA 701-800

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FOG2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur ZFPM2

Antigène: ZFPM2 (Zinc Finger Protein, FOG Family Member 2 (ZFPM2))

Autre désignation: FOG2

Sujet:

Synonyms: FOG-2, FOG2_HUMAN, Friend of GATA 2, Friend of GATA protein 2, Friend of GATA2 , hFOG-2 , ZFPM2, Zinc finger protein 89B, Zinc finger protein M2, Zinc finger protein multitype 2 , Zinc finger protein ZFPM2.

Background: The FOG family of transcriptional cofactors, including FOG (friend of GATA-1) and FOG-2, are zinc finger proteins that interact with the GATA family of transcriptional regulators. FOG/GATA-1 complexes are required for erythroid and megakaryocyte maturation, and they promote differentiation during embryonic development. These complexes involve the association between multiple zinc fingers on the FOG proteins and the N-terminal zinc finger of GATA proteins. While FOG cooperatively regulates GATA-1 induced transcription, FOG-2 is able to both positively and negatively influence GATA mediated transcription. FOG-2 is predominantly expressed in heart, neurons and gonads, and it preferentially participates in the regulation of GATA-3, GATA-4 and GATA-6. In cardiomyocytes and fibroblasts, FOG-2 inhibits GATA-4 transcriptional activity, yet FOG-2 restores GATA-1 mediated transcription in erythroid cultures deficient in FOG, suggesting that the observed effects of FOG-2 are context specific and vary between cellular systems.