ANK2 anticorps (AA 1901-2100)

N° du produit ABIN1386782

L’anticorps Lapin Polyclonal anti-ANK2 a été validé pour IHC (p), ELISA, IF (cc), IF (p) et IHC (fro). Il convient pour détecter ANK2 dans des échantillons de Souris.

Aperçu rapide pour ANK2 anticorps (AA 1901-2100) (ABIN1386782)

Antigène: ANK2 (Ankyrin 2, Neuronal (ANK2))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ANK2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-ANK2 anticorps

Épitope: AA 1901-2100

Réactivité croisée: Souris

Homologie: Human,Rat,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Ankyrin B

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur ANK2

Antigène: ANK2 (Ankyrin 2, Neuronal (ANK2))

Autre désignation: Ankyrin B

Sujet:

Synonyms: ANK-2, Ank2, ANK2_HUMAN, Ankyrin 2, Ankyrin 2 brain, Ankyrin B, Ankyrin nonerythroid, ANKYRIN, NEURONAL, Ankyrin-2, Ankyrin-B, Brain ankyrin, Non-erythroid ankyrin

Background: Members of the Ankyrin family of proteins mediate the attachment of integral membrane proteins to the cytoskeleton. ANK1, ANK2 and ANK3 genes encode for the proteins in this family, Ankyrin-1 (also designated Ankyrin R), Ankyrin B and Ankyrin G, respectively. The proteins are structured similarly each composed of an N-terminal domain with multiple ankyrin repeats, a highly conserved central spectrin binding domain, and C-terminal regulatory domains which are susceptible to the most variance. Both Ankyrin B and Ankyrin G are essential for normal neuronal functions. Ankyrin B, or brain Ankyrin is predominantly expressed in the plasma membrane of neurons as well as glial cells throughout the brain. Two transcripts have been described with alternative splicing resulting in additional isoforms. The Ankyrin B protein associates with the spectrin-actin network, mediates axon fasciculation, and stabilizes axon bundles. Ankyrin B is required for coordinated assembly of Na/Ca exchanger, Na/K ATPase, and inositol trisphosphate (InsP(3)) receptor at transverse-tubule/sarcoplasmic reticulum sites in cardiomyocytes.

ID gène: 287

Pathways: Cell-Cell Junction Organization