DR1 anticorps

N° du produit ABIN1386906

Détail du produit anti-DR1 anticorps

Antigène: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DR1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human DR1 protein

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur DR1

Antigène: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Autre désignation: DR1 Protein (DR1 Produits)

Synonymes: anticorps BG:DS00929.3, anticorps CG4185, anticorps Dmel\\CG4185, anticorps Dr1, anticorps NC2 beta, anticorps Nc2b, anticorps dDr1, anticorps dNC2, anticorps wu:fj15f04, anticorps zgc:152914, anticorps 1700121L09Rik, anticorps Dr1l, anticorps NC2, anticorps NC2beta, anticorps NC2-BETA, anticorps Negative Cofactor 2beta, anticorps TATA-BINDING PROTEIN-ASSOCIATED PHOSPHOPROTEIN, anticorps TATA-binding protein-associated phosphoprotein, anticorps putative tata-binding protein-associated phosphoprotein, anticorps down-regulator of transcription 1, anticorps down-regulator of transcription 1, TBP-binding (negative cofactor 2), anticorps NC2beta, anticorps ECU11_0730, anticorps EDI_229030, anticorps PTRG_08168, anticorps Smp_160150, anticorps EBI_26279, anticorps EBI_23074, anticorps VDBG_02216, anticorps dr1, anticorps Dr1, anticorps DR1

Sujet:

Synonyms: Dr1 protein; NC2; Negative cofactor 2 beta; Down regulator of transcription 1; Down regulator of transcription 1 TBP binding; Down-regulator of transcription 1; DR 1; Dr1; NC 2; NC2 beta; NC2-beta; NC2B_HUMAN; Negative co factor 2; Negative cofactor 2; Negative cofactor 2-beta; Protein Dr1; TATA binding protein associated phosphoprotein; TATA-binding protein-associated phosphoprotein.

Background: DR1, also known as NC2 (negative cofactor 2 subunit ), is a TFIID (TATA box-binding protein)-associated protein. DR1 localizes to the nucleus and contains an N-terminal histone fold motif, a TFIID-binding domain and an alanine and glutamine rich region. Via its histone fold motif, DR1 forms a heterodimer with NC2å (DRAP1) to comprise the conserved eukaryotic complex, NC2 (negative cofactor 2). The NC2 complex can both positively and negatively regulate transcription by RNA Pol II. More specifically, NC2 acts as a repressor of TATA-dependent transcription and acts as an activator for DPE-dependent transcription. NC2 represses RNA Pol II transcription by binding to TFIID and inhibiting association of the transcription factors TFIIA and TFIIB. NC2 activity is regulated by phosphorylation. Both subunits, NC2å and DR1, are phosphorylated in vivo.

ID gène: 10589