Akirin 1 anticorps

N° du produit ABIN1386924

Détail du produit anti-Akirin 1 anticorps

Antigène: Akirin 1 (AKIRIN1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Akirin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human AKIRIN1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Akirin 1

Antigène: Akirin 1 (AKIRIN1)

Autre désignation: AKIRIN1 (AKIRIN1 Produits)

Synonymes: anticorps C1orf108, anticorps RP11-781D11.2, anticorps STRF2, anticorps 6330407G11Rik, anticorps wu:fa96c11, anticorps wu:fc08a11, anticorps zgc:64050, anticorps AKIRIN1, anticorps strf2, anticorps akirin 1, anticorps akirin 1 S homeolog, anticorps akirin-1 pseudogene, anticorps AKIRIN1, anticorps Akirin1, anticorps akirin1, anticorps akirin1.S, anticorps LOC100316864, anticorps LOC100356339

Sujet:

Synonyms: AKIRIN 1, C1orf108, FLJ12666, OTTHUMP00000008669, RP11-781D11.2, STRF2, AKIR1_HUMAN.

Background: AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways.