SASS6 anticorps

N° du produit ABIN1387012

Détail du produit anti-SASS6 anticorps

Antigène: SASS6 (Spindle Assembly 6 Homolog (SASS6))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SASS6 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SASS6

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur SASS6

Antigène: SASS6 (Spindle Assembly 6 Homolog (SASS6))

Autre désignation: SASS6 (SASS6 Produits)

Synonymes: anticorps SAS-6, anticorps SAS6, anticorps 2810453L12Rik, anticorps RGD1306255, anticorps CG15524, anticorps DSAS-6, anticorps DSas-6, anticorps DSas6, anticorps Dmel\\CG15524, anticorps Dsas6, anticorps Sas-6, anticorps Sas6, anticorps dsas-6, anticorps sas6, anticorps wu:fb98c12, anticorps zgc:55668, anticorps SASS6, anticorps sass6.2, anticorps SAS-6 centriolar assembly protein, anticorps Spindle assembly abnormal 6, anticorps spindle assembly 6 homolog L homeolog, anticorps SAS-6 centriolar assembly protein L homeolog, anticorps SASS6, anticorps Sass6, anticorps Sas-6, anticorps sass6.L, anticorps sass6, anticorps sass6.2.L

Sujet:

Synonyms: HsSAS 6, HsSAS6, MGC119440, SAS 6, SAS6, SASS 6, Spindle assembly 6 homolog C. elegans, Spindle assembly 6 homolog, Spindle assembly abnormal protein 6 homolog, PJA2_HUMAN.

Background: SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle, it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.

ID gène: 163786