PSMA7 anticorps

N° du produit ABIN1387047

Détail du produit anti-PSMA7 anticorps

Antigène: PSMA7 (Proteasome Subunit alpha 7 (PSMA7))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSMA7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Proteasome 20S alpha 7

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur PSMA7

Antigène: PSMA7 (Proteasome Subunit alpha 7 (PSMA7))

Abstract: PSMA7 Produits

Synonymes: anticorps C6, anticorps HSPC, anticorps RC6-1, anticorps XAPC7, anticorps C6-I, anticorps DDBDRAFT_0185059, anticorps DDBDRAFT_0217080, anticorps DDB_0185059, anticorps DDB_0217080, anticorps hspc, anticorps rc6-1, anticorps xapc7, anticorps psma7, anticorps psma4-B, anticorps proteasome subunit alpha 7, anticorps proteasome (prosome, macropain) subunit, alpha type 7, anticorps 20S proteasome subunit alpha-7, anticorps proteasome subunit alpha 7 S homeolog, anticorps proteasome subunit alpha 7 L homeolog, anticorps PSMA7, anticorps Psma7, anticorps psmA7, anticorps psma7, anticorps psma7.S, anticorps psma7.L

Sujet:

Synonyms: C6 antibody HSPC, Proteasome prosome macropain subunit alpha type 7, Proteasome alpha 7 subunit, Proteasome subunit alpha 4, Proteasome subunit alpha type 7, Proteasome subunit alpha type-7, Proteasome subunit RC6 1, Proteasome subunit RC6-1, Proteasome subunit XAPC7, PSA7_HUMAN, PSMA7, RC6 1, XAPC7.

Background: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH . The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

ID gène: 5688

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA