UBE2K anticorps (AA 51-150)

N° du produit ABIN1387369

Détail du produit anti-UBE2K anticorps

Antigène: UBE2K (Ubiquitin-Conjugating Enzyme E2K (UBE2K))

Épitope: AA 51-150

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBE2K est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Rat

Homologie: Human,Mouse,Dog,Cow,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HIP2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur UBE2K

Antigène: UBE2K (Ubiquitin-Conjugating Enzyme E2K (UBE2K))

Autre désignation: HIP2 (UBE2K Produits)

Synonymes: anticorps E2-25K, anticorps HIP2, anticorps HYPG, anticorps LIG, anticorps UBC1, anticorps E2-25k, anticorps Hip2, anticorps Hypg, anticorps Lig, anticorps e2-25k, anticorps hip2, anticorps hypg, anticorps lig, anticorps AW492011, anticorps D5Ertd601e, anticorps ube2k, anticorps zgc:103472, anticorps zgc:110791, anticorps ubiquitin conjugating enzyme E2 K, anticorps ubiquitin-conjugating enzyme E2K, anticorps ubiquitin conjugating enzyme E2 K S homeolog, anticorps ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast), anticorps ubiquitin-conjugating enzyme E2Ka (UBC1 homolog, yeast), anticorps UBE2K, anticorps Ube2k, anticorps ube2k.S, anticorps ube2k, anticorps ube2kb, anticorps ube2ka

Sujet:

Synonyms: LIG, HIP2, HYPG, UBC1, E2-25K, Ubiquitin-conjugating enzyme E2 K, Huntingtin-interacting protein 2, HIP-2, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2-25 kDa, Ubiquitin-conjugating enzyme E2(25K), Ubiquitin-conjugating enzyme E2-25K, Ubiquitin-protein ligase, UBE2K

Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B, in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.

ID gène: 3093

UniProt: P61086