PHOX2A anticorps (AA 41-140)

N° du produit ABIN1387382

L’anticorps Lapin Polyclonal anti-PHOX2A a été validé pour WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) et ICC. Il convient pour détecter PHOX2A dans des échantillons de Humain.

Aperçu rapide pour PHOX2A anticorps (AA 41-140) (ABIN1387382)

Antigène: PHOX2A (Paired-Like Homeobox 2a (PHOX2A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHOX2A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Détail du produit anti-PHOX2A anticorps

Épitope: AA 41-140

Homologie: Human,Mouse,Rat,Cow,Sheep,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PHOX2A

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur PHOX2A

Antigène: PHOX2A (Paired-Like Homeobox 2a (PHOX2A))

Autre désignation: PHOX2A/CFEOM2

Sujet:

Synonyms: Aristaless homeobox Drosophila fibrosis of extraocular muscles congenital 2 autosomal recessive, Aristaless homeobox gene homolog Drosophila, Aristaless homeobox homolog, Aristaless homeobox protein homolog, ARIX 1 homeodomain protein, ARIX, Arix homeodomain protein, ARIX1 homeodomain protein, CFEOM 2, CFEOM2, FEOM 2, FEOM2, Fibrosis of extraocular muscles congenital 2 autosomal recessive, MGC52227, NCAM 2, NCAM2, Paired like aristaless Homeobox 2A, Paired like homeobox 2a, Paired mesoderm homeobox 2a, Paired mesoderm homeobox protein 2A, Paired-like homeobox 2A, PHOX 2A, Phox2, Phox2a, PHX2A_HUMAN, Pmx 2a, Pmx2, Pmx2a.

Background: Phox2a (also designated Arix1) and Phox2b are closely related, paired-homeodomain transcription factors that are necessary for neuronal differentiation throughout the developing sympathetic, parasympathetic and enteric ganglia. All enteric nervous system cells evolve from the neural crest, and all cells that are undifferentiated initially express Phox2b. The cells that begin to differentiate along a neuronal lineage continue to express Phox2b, and begin to express Phox2a. Phox2b is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, Phox2a controls only the differentiation of the main noradrenergic center of the brain, the locus ceruleus. Both Phox2a and Phox2b are crucial for the regulation of endogenous tyrosine hydroxylase and dopamine-beta hydroxylase, which are transiently expressed in neural crest cells. In addition, Phox2 proteins are sufficient to promote sympathetic neuron generation. The gene which encodes Phox2a maps to human chromosome 11q13.3-q13.4.