ATRIP anticorps

N° du produit ABIN1387408

Cet anticorps Lapin Polyclonal détecte spécifiquement ATRIP dans WB, IHC (p) et IF (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ATRIP anticorps (ABIN1387408)

Antigène: ATRIP (ATR Interacting Protein (ATRIP))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATRIP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-ATRIP anticorps

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ATRIP

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur ATRIP

Antigène: ATRIP (ATR Interacting Protein (ATRIP))

Autre désignation: ATRIP/TREX1

Sujet:

Synonyms: AGS 1, AGS1, AGS-1, Aicardi Goutieres syndrome 1, ATIP, ATM and Rad3 related interacting protein, ATM and Rad3-related-interacting protein, ATR interacting protein, ATR-interacting protein, Atrip, ATRIP_HUMAN, Deoxyribonuclease III dnaQ/mutD E. coli like, DKFZp434J0310, DKFZp762J2115, DNase III, DRN 3, DRN3, FLJ12343, MGC20625, MGC26740, Three prime repair exonuclease 1, TREX 1, TREX1, TREX1 protein, MGC21482, 3' repair exonuclease 1, 3'-5' exonuclease TREX1.

Background: DNA damage or incomplete replication of DNA results in the inhibition of cell cycle progression at the G1 to S or the G2 to M phase transition by conserved regulatory mechanisms known as cell cycle checkpoints. Checkpoint proteins include Rad17, which is involved in regulating cell cycle progression at the G1 checkpoint as well as Chk1, Chk2, Rad1, Rad9 and Hus1, which are involved in regulating cell cycle arrest at the G2 checkpoint. In response to DNA damage, ATM and ATR kinases are important for cell cycle checkpoint response signalling. ATR-interacting protein (ATRIP), also designated ATM and Rad3-related-interacting protein, is required for checkpoint signaling after DNA damage. It is also important for ATR expression, which regulates DNA replication and damage checkpoint responses. ATRIP is a ubiquitously expressed protein that can form heterodimers with ATR. After dimerization they bind the RPA complex and are recruited to single stranded DNA. ATRIP is a nuclear protein that may also play a role in protein stabilization.