Proteoglycan 4 anticorps (AA 1151-1250)

N° du produit ABIN1387463

L’anticorps Lapin Polyclonal anti-Proteoglycan 4 a été validé pour WB, ELISA, ICC, IF (cc), IF (p), IHC (fro) et IHC (p). Il convient pour détecter Proteoglycan 4 dans des échantillons de Souris, Rat et Lapin.

Aperçu rapide pour Proteoglycan 4 anticorps (AA 1151-1250) (ABIN1387463)

Antigène: Proteoglycan 4 (PRG4)

Reactivité: Souris, Rat, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Proteoglycan 4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Proteoglycan 4 anticorps

Épitope: AA 1151-1250

Réactivité croisée: Souris, Lapin, Rat

Homologie: Human,Dog,Cow

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Lubricin/SZP

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Proteoglycan 4

Antigène: Proteoglycan 4 (PRG4)

Autre désignation: Lubricin/SZP

Sujet:

Synonyms: Superficial zone proteoglycan, articular superficial zone protein, bG174L6.2, CACP, camptodactyly arthropathy coxa vara pericarditis syndrome gene, FLJ32635, HAPO, Jacobs camptodactyly-arthropathy-pericarditis syndrome gene, JCAP, megakaryocyte stimulating factor, MSF, PRG 4, PRG4, proteoglycan 4, Proteoglycan4, Superficial zone proteoglycan, SZP.

Background: Lubricin, also designated proteoglycan-4 or megakaryocyte stimulating factor, is important for boundary lubrication within articulating joints. It is a disulfide-linked homodimer (between Cysteine 1146 and Cysteine 1403) that is essential for protein cleavage. Lubricin inhibits synovial cell adhesion to the cartilage surface, but also prevents the deposition of proteins from synovial fluid onto cartilage. Lubricin is highly expressed in cartilage, liver and synovial tissue. Defects in the gene encoding for lubricin can cause Jakobs syndrome, also designated camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP). CACP is an autosomal recessive disorder characterized by joint failure associated with noninflammatory synoviocyte hyperplasia and subinitimal fibrosis of the synovial capsule. Lubricin undergoes different levels of glycosylation and may be detected at varying molecular weights.

ID gène: 10216

UniProt: Q92954