ANT1+ANT2+ANT3+ANT4 anticorps

N° du produit ABIN1387829

Détail du produit

Antigène: ANT1+ANT2+ANT3+ANT4

Reactivité: Souris, Rat, Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ANT1/2/3/4

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: ANT1+ANT2+ANT3+ANT4

Sujet:

Synonyms: ATP carrier protein 1, ADP ATP carrier protein heart/skeletal muscle isoform T1, ADP/ATP translocase 1, ADT1_HUMAN, ANT 1, ANT, ANT1, ATP carrier protein 2, ADP ATP carrier protein heart/skeletal muscle isoform T2, ADP/ATP translocase 2, ADT2_HUMAN, ANT 2, ANT, ATP carrier protein 3, ADP ATP carrier protein heart/skeletal muscle isoform T3, ADP/ATP translocase 3, ADT3_HUMAN, ANT3, ATP carrier protein 4, ADP ATP carrier protein heart/skeletal muscle isoform T4, ADP/ATP translocase 4, ADT4_HUMAN, ANT 4,ANT4.

Background: Adenine nucleotide translocator (ANT) and the voltage-dependent anion-selective channel proteins 1 and 2 (VDAC1 and VDAC2) are components of the permeability transition pore complex (PTPC) of the mitochondrial inner and outer membranes, respectively. Formation of PTPCs, the subsequent dissipation of mitochondrial inner membrane potential and release of cytochrome c through the outer mitochondrial membrane are critical events in the early stages of apoptosis. Bax, a proapoptotic protein, has been shown to act upon ANT to induce the dissipation of mitochondrial inner membrane potential. ANT1 has a role in the maintenance of mitochondrial DNA by catalyzing the exchange of ADP and ATP across the mitochondrial inner membrane.