MYRIP anticorps (AA 101-200)

N° du produit ABIN1387849

Cet anticorps Lapin Polyclonal détecte spécifiquement MYRIP dans ELISA, WB, IHC (p), ICC, IF (cc), IF (p) et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour MYRIP anticorps (AA 101-200) (ABIN1387849)

Antigène: MYRIP (Myosin VIIA and Rab Interacting Protein (MYRIP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYRIP est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-MYRIP anticorps

Épitope: AA 101-200

Homologie: Human,Mouse,Rat,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human MYRIP/SLAC2-C

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur MYRIP

Antigène: MYRIP (Myosin VIIA and Rab Interacting Protein (MYRIP))

Autre désignation: MYRIP/SLAC2-C

Sujet:

Synonyms: exophilin 8, exophilin, Exophilin-8, Exophilin8, Myosin VIIA and Rab interacting protein, Myosin-VIIa- and Rab-interacting protein, MyRIP, MYRIP_HUMAN, rab effector MYRIP, SLAC 2C, SLAC2 C, SLAC2-C, SLAC2C, Slp homolog lacking C2 domains c, Slp homologue lacking C2 domains, Slp homologue lacking C2 domains c antibody Synaptotagmin like protein homologue lacking C2 domains c, synaptotagmin-like protein homologue lacking C2 domains-c.

Background: Slac2-c is a Rab effector protein that is expressed in a variety of tissues including brain, heart, skin and liver. Found in the basal microvilli of retinal pigment cells and in pre- and post-synaptic areas in photoreceptor cells , Slac2-c is involved in melanosome transport and functions to link Rab 27a with the actin-based motor proteins Myosin Va and Myosin VIIa. Once linked, the Myosins are able to transport Rab 27a to retinal melanosomes, thereby linking the actin cytoskeleton with the melanosome membrane. Slac2-c contains one FYVE-type zinc finger and one Rab-binding domain and is able to bind actin-like proteins through its conserved C-terminal region. Additionally, Slac2-c is thought to regulate the final steps of insulin exocytosis by mediating the interaction of secretory granules with the cortical actin cytoskeleton.

Pathways: Positive Regulation of Peptide Hormone Secretion