MTMR14 anticorps (AA 161-260) (AbBy Fluor® 647)

N° du produit ABIN1389966

Cet anticorps anti-MTMR14 est un anticorps Lapin Polyclonal détectant MTMR14 dans WB, IF (cc) et IF (p). Adapté pour Souris.

Aperçu rapide pour MTMR14 anticorps (AA 161-260) (AbBy Fluor® 647) (ABIN1389966)

Antigène: MTMR14 (Myotubularin Related Protein 14 (MTMR14))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTMR14 est conjugé à/à la AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-MTMR14 anticorps (AbBy Fluor® 647)

Épitope: AA 161-260

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human MTMR14

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur MTMR14

Antigène: MTMR14 (Myotubularin Related Protein 14 (MTMR14))

Autre désignation: MTMR14

Sujet:

Synonyms: C3orf29, Egg derived tyrosine phosphatase homolog, FLJ11546, FLJ22405, FLJ46453, FLJ90311, HCV NS5A transactivated protein 4 splice variant A binding protein 1, HCV NS5A-transactivated protein 4 splice variant A-binding protein 1, hJumpy, jumpy, MTMR 14, MTMR14, MTMR-14, MTMRE_HUMAN, Myotubularin related protein 14, Myotubularin-related protein 14, NS5ATP4ABP1.

Background: Myotubularin-related protein 14 (MTMR14), also known as Jumpy, is a myotubularin-related phosphoinositol-3-phosphate (PI3P) phosphatase (1). Mutations in the MTMR14 gene have been associated with centronuclear myopathy (1). MTMR14 deficiency in mice leads to altered calcium homeostasis and muscle disorders (2). MTMR14 has also been shown to play a role in autophagy, a process that is highly regulated by phosphatidylinositides through the type III PI3K, Vps34 (3). MTMR14 was localized to autophagic isolation membranes and early autophagosomes (3). In these studies, MTMR14 inhibited autophagy and mutations of MTMR14 associated with centronuclear myopathy were also defective in autophagy inhibition. In zebrafish, MTMR14 knockdown was shown to increase the number of autophagosomes, suggesting that its activity is associated with an inhibition of autophagy (4).

Pathways: Inositol Metabolic Process