XPO5 anticorps (AA 221-320) (Biotin)

N° du produit ABIN1389979

Détail du produit anti-XPO5 anticorps (Biotin)

Antigène: XPO5 (Exportin 5 (XPO5))

Épitope: AA 221-320

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XPO5 est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Exportin 5

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur XPO5

Antigène: XPO5 (Exportin 5 (XPO5))

Autre désignation: Exportin 5 (XPO5 Produits)

Synonymes: anticorps exp5, anticorps CG12234, anticorps Dmel\\CG12234, anticorps Exp-5, anticorps Exp5, anticorps RanBP21, anticorps dmExp5, anticorps 2410004H11Rik, anticorps 2700038C24Rik, anticorps AI648907, anticorps AW549301, anticorps RanBp21, anticorps mKIAA1291, anticorps exportin-5, anticorps ranbp21, anticorps DDBDRAFT_0185980, anticorps DDBDRAFT_0237583, anticorps DDB_0185980, anticorps DDB_0237583, anticorps XPO5, anticorps exportin 5, anticorps CG12234 gene product from transcript CG12234-RB, anticorps armadillo-like helical domain-containing protein, anticorps XPO5, anticorps Ranbp21, anticorps Xpo5, anticorps xpo5

Sujet:

Synonyms: Exp 5, Exp5, Exportin 5, Exportin-5, Exportin5, FLJ14239, FLJ32057, FLJ45606, KIAA1291, Ran binding protein 21, Ran-binding protein 21, Ranbp 21, Ranbp21, Xpo 5, xpo5, XPO5_HUMAN.

Background: Exportin 5 (XPO5) is a member of the importin _ family of proteins and functions in tRNA export in a sequence dependent fashion. More recently, it has been shown to export pre-miRNA by a RanGTPase-driven process from the nucleus to the cytoplasm, where pre-miRNA processing occurs to produce mature miRNAs. Study of the miRNA biosynthesis pathway is essential in understanding the process of oncogenesis as global downregulation of miRNAs and the resulting alterations in the expression of tumor suppressor and oncogenic proteins is a common phenotype of cancers cells . Research studies have shown disruption of exportin 5 functions in many types of cancers including breast and lung, where pre-miRNA accumulates in the nucleus and miRNA maturation is impaired.

Pathways: Regulatory RNA Pathways, Protein targeting to Nucleus