DMO/Dmrt1a (AA 51-100) anticorps (AbBy Fluor® 555)

N° du produit ABIN1390307

L’anticorps anti-DMO/Dmrt1a Polyclonal Lapin est utilisé pour la détection de DMO/Dmrt1a dans des échantillons de Humain. Il a été validé pour WB, IF (cc) et IF (p).

Aperçu rapide pour DMO/Dmrt1a (AA 51-100) anticorps (AbBy Fluor® 555) (ABIN1390307)

Antigène: DMO/Dmrt1a

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit

Épitope: AA 51-100

Fonction: DMRT1 Polyclonal Antibody, AbBy Fluor-555 Conjugated

Réactivité croisée: Humain, Rat

Homologie: Mouse,Dog,Sheep,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human DMRT1

Isotype: IgG

Information d'application

Indications d'application: WB(1:300-5000), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: DMO/Dmrt1a

Sujet:

Synonyms: DMT1, CT154, Doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis protein 1, DMRT1

Background: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).

ID gène: 1761

UniProt: Q9Y5R6