Hsp 40-4/Hdj2/Dnaja1 (AA 21-110) anticorps (AbBy Fluor® 488)

N° du produit ABIN1390312

Cet anticorps Lapin Polyclonal détecte spécifiquement dans WB, IF (cc) et IF (p). Il présente une réactivité envers Souris.

Aperçu rapide pour Hsp 40-4/Hdj2/Dnaja1 (AA 21-110) anticorps (AbBy Fluor® 488) (ABIN1390312)

Antigène: Hsp 40-4/Hdj2/Dnaja1

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit

Épitope: AA 21-110

Réactivité croisée: Souris

Homologie: Human,Rat,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HSP 40-4

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Hsp 40-4/Hdj2/Dnaja1

Sujet:

Synonyms: DJ 2, DJ2, DjA1, DnaJ Hsp40 homolog, subfamily A, member 1, DnaJ homolog subfamily A member 1, DnaJ protein homolog 2, DNAJ2, Dnaja1, DNJA1_HUMAN, hDJ 2, HDJ-2, HDJ2, Heat shock 40 kDa protein 4, heat shock protein DNAJ like 2, Heat shock protein J2, HSDJ, HSJ-2, HSJ2, HSPF4, Human DnaJ protein 2, NEDD7, Neural precursor cell expressed developmentally down regulated 7, OTTHUMP00000021193.

Background: DnaJ-like proteins interact with HSP 70 Molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.