Complexin 1 anticorps (AA 31-100) (AbBy Fluor® 488)

N° du produit ABIN1390696

Cet anticorps Lapin Polyclonal détecte spécifiquement Complexin 1 dans WB, IF (cc) et IF (p). Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour Complexin 1 anticorps (AA 31-100) (AbBy Fluor® 488) (ABIN1390696)

Antigène: Complexin 1 (CPLX1)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Complexin 1 est conjugé à/à la AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Complexin 1 anticorps (AbBy Fluor® 488)

Épitope: AA 31-100

Réactivité croisée: Souris, Rat

Homologie: Human,Cow,Pig,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CPLX1

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Complexin 1

Antigène: Complexin 1 (CPLX1)

Autre désignation: CPLX1

Sujet:

Synonyms: complexin 1, Complexin I, Complexin-1, CPLX1, CPLX1_HUMAN, CPX I, CPX-I, CPX1, Synaphin 2, Synaphin-2, 921-S.

Background: Complexin 1 and Complexin 2, also designated Synaphin 1 and Synaphin 2, contain an a-helical middle domain of approximately 58 amino acids. Complexin 1 and Complexin 2 are expressed in presynaptic terminals of inhibitory and excitatory hippocampal neurons, respectively, and in cytoplasmic pools during early stages of development. Complexins promote SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) precomplex formation by binding to synaxin with its a-helical domain. Complexins are important regulators of transmitter release at a late step in calcium dependent neurotransmitter release or immediately after the calcium-triggering step of fast synchronous transmitter release and preceding vesicle fusion. Neurons lacking complexins show reduced transmitter release efficiency due to decreased calcium sensitivity of the synaptic secretion process. Complexin 2 may play a role in LTP (long term potentiation) following tetanic stimulation. A progressive loss of Complexin 2 occurs in the brains of mice carrying the Huntington disease mutation, an autosomal dominant neurodegenerative disorder. Changes in the neurotransmitter release might contribute to the motor, emotional and cognitive dysfunctions seen in these mice.

Pathways: Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport