Utrophin anticorps (AbBy Fluor® 647)

N° du produit ABIN1391016

Cet anticorps anti-Utrophin est un anticorps Lapin Polyclonal détectant Utrophin dans FACS. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Utrophin anticorps (AbBy Fluor® 647) (ABIN1391016)

Antigène: Utrophin (UTRN)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Utrophin est conjugé à/à la AbBy Fluor® 647

Application: Flow Cytometry (FACS)

Détail du produit anti-Utrophin anticorps (AbBy Fluor® 647)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Utrophin

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P): 1:50-200
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Utrophin

Antigène: Utrophin (UTRN)

Autre désignation: Utrophin

Sujet:

Synonyms: DMDL, DRP 1, DRP, DRP-1, DRP1, Dystrophin like protein, Dystrophin related protein 1, Dystrophin related protein, Dystrophin-related protein 1, FLJ23678, UTRN, UTRO_HUMAN, Utrophin homologous to dystrophin, Utrophin

Background: Dystrophin and utrophin are related structural, Actin-binding proteins that are involved in anchoring the cytoskeleton to the plasma membrane. Dystrophin is the protein product of the Duchenne/Becker muscular dystrophy gene. Dystrophin expression is found in muscle and brain tissues, where it is localized to the inner surface of the plasma membrane. It has been speculated that alternative splicing of the carboxy terminus allows dystrophin to interact with a variety of proteins. Research has shown that the loss of dystrophin-associated proteins in Duchenne afflicted muscle is due to the absence of dystrophin rather than to muscle degradation and that the lack of dystrophin results in the loss of linkage between the cytoskeleton and the extracellular matrix. Evidence suggests that the upregulation of utrophin can reduce the dystrophic pathology.

ID gène: 7402

Pathways: Skeletal Muscle Fiber Development