MED7 anticorps (AA 101-200) (Biotin)

N° du produit ABIN1391215

Détail du produit anti-MED7 anticorps (Biotin)

Antigène: MED7 (Mediator Complex Subunit 7 (MED7))

Épitope: AA 101-200

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MED7 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Zebrafish

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CRSP9

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur MED7

Antigène: MED7 (Mediator Complex Subunit 7 (MED7))

Autre désignation: CRSP9 (MED7 Produits)

Synonymes: anticorps ARC34, anticorps CRSP33, anticorps CRSP9, anticorps 1110063B05Rik, anticorps Crsp33, anticorps Crsp9, anticorps crsp9, anticorps wu:fd99d12, anticorps zgc:56241, anticorps crsp9-A, anticorps med7-a, anticorps mediator complex subunit 7, anticorps mediator complex subunit 7 L homeolog, anticorps mediator complex subunit, anticorps mediator complex subunit Med7, anticorps MED7, anticorps Med7, anticorps med7, anticorps med7.L

Sujet:

Synonyms: Cofactor required for Sp1 transcriptional activation subunit 9, CRSP complex subunit 9, CRSP33, hMED7, MED7, MED7_HUMAN, Mediator complex subunit 7, Mediator of RNA polymerase II transcription subunit 7, MGC12284, RNA polymerase transcriptional regulation mediator subunit 7 homolog, Transcriptional coactivator CRSP33, Activator recruited cofactor 34 kDa component, Activator-recruited cofactor 34 kDa component, ARC34.

Background: In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase (1). These complexes include the SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes, and including the human proteins Srb7, Med6 (also designated DRIP33) and Med7 (also designated DRIP34) (2,3). SMCC associates with the RNAPII (RNA polymerase II) holoenzyme through Srb7 and, in turn, enhances gene-specific activation or repression induced by DNA-binding transcription factors (4). Med6 and Med7, as well as other components of SMCC, associate with coactivator proteins from the TRAP (thyroid hormone receptor-activating protein) complex and DRIP (for vitamin D receptor interacting protein) complex to facilitate steroid receptor dependent transcriptional activation (4,5). Additionally, SMCC associates with PC4 (positive cofactor 4) to repress basal transcription independent of RNAPII activity (6).

ID gène: 9443

Pathways: Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha