EN2 anticorps (AA 281-333) (Biotin)

N° du produit ABIN1391947

Cet anticorps Lapin Polyclonal détecte spécifiquement EN2 dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Humain et Souris et a été mentionné dans 1 publication.

Aperçu rapide pour EN2 anticorps (AA 281-333) (Biotin) (ABIN1391947)

Antigène: EN2 (Engrailed Homeobox 2 (EN2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EN2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-EN2 anticorps (Biotin)

Épitope: AA 281-333

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Sheep,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human EN2/Engrailed 2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Références pour anticorps anti-EN2 (Biotin) (ABIN1391947)

De Paoli, Gogalic, Sauer, Preininger, Pandha, Simpson, Horvath, Marquette: "Multiplatform Biomarker Discovery for Bladder Cancer Recurrence Diagnosis." dans: Disease markers, Vol. 2016, pp. 4591910, (2016) (PubMed).

Détails sur EN2

Antigène: EN2 (Engrailed Homeobox 2 (EN2))

Autre désignation: EN2/Engrailed 2

Sujet:

Synonyms: Homeobox protein engrailed-2, Homeobox protein en-2, Hu-En-2, EN2

Background: The engrailed-2 gene, EN2, a murine homolog of the Drosophila homeobox gene engrailed (EN), is required for midbrain and cerebellum development and dorsal/ventral patterning of the limbs as well as apical ectodermal ridge formation. In Drosophila, the EN gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Human EN-1 and EN-2 are homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Different mutations in the mouse homologs, EN-1 and EN-2, produce different developmental defects that frequently are lethal. EN-1 is highly expressed by essentially all dopaminergic neurons in the substantia nigra and ventral tegmentum. EN-1 and EN-2 regulate expression of a-synuclein, a gene that is genetically linked to Parkinson?s disease. During early brain development mouse EN-2 is expressed in a broad band across most of the mid-hindbrain region. EN-2 is also expressed in mouse myoblasts and has been assiciated with cerebellar hypoplasia.

ID gène: 2020

UniProt: P19622